Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

Atherosclerosis is characterized by the plaque formation that restricts intraarterial blood flow.
The disturbed blood flow with the associated oscillatory stress (OS) at the arterial curvatures …

Overcoming drug resistance is an inevitable challenge to the success of cancer treatment.
Recently, in ovarian cancer, a highly chemoresistant tumor, we demonstrated an important …

In this study, we developed an AS1411 aptamer/hyaluronic acid-bifunctionalized
microemulsion co-loading shikonin and docetaxel (AS1411/SKN&DTX-M). Such …

Disorders of miR-484 expression are observed in cancer, different diseases or pathological
states. There is accumulating evidence that miR-484 plays an essential role in the …

Background and aims Mitophagy plays a crucial role in mitochondrial homeostasis and is
closely associated with endothelial function. However, the mechanism underlying low blood …

Lining the luminal surface of the vasculature, endothelial cells (ECs) are in direct contact
with and differentially respond to hemodynamic forces depending on their anatomic location …

A high level of nucleolin (NCL) expression is often associated with a poor prognosis of
patients with lung cancer (LC), suggesting that NCL can be used as a possible biomarker …

Hyperglycemia in diabetes mellitus impairs endothelial function and disrupts microRNA
(miRNA) profiles in vasculature, increasing the risk of diabetes-associated complications …