Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

Conspectus The functionalization of unactivated carbon–hydrogen bonds is a transformative
strategy for the rapid construction of molecular complexity given the ubiquitous presence of …

Conspectus Aromatic structures are widespread motifs throughout organic chemistry, and C–
H activation has been recognized as a major tool for enabling their sustainable and efficient …

Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds
represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of …

The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

Computational studies on carboxylate-assisted C–H activation and functionalization at
group 8–10 transition metal centers are reviewed. This Review is organized by metal and …

Direct C–H functionalization has recently emerged as one of the most efficient strategies to
access structurally complex molecules from readily accessible feedstocks in an atom-and …

C− C bond formation is a fundamental transformation in organic synthesis. The development
of new synthetic methodology could be considered as a way of pursuing a novel method for …

Palladium-catalyzed aerobic oxidation reactions have been the focus of industrial
application and extensive research efforts for nearly 60 years. A significant transition …