Immunopathology of chronic hepatitis B infection: role of innate and adaptive immune response in disease progression

A Khanam, JV Chua, S Kottilil - International Journal of Molecular …, 2021 - mdpi.com
More than 250 million people are living with chronic hepatitis B despite the availability of
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …

Recent advancements in antifibrotic therapies for regression of liver fibrosis

A Jangra, A Kothari, P Sarma, B Medhi, BJ Omar… - Cells, 2022 - mdpi.com
Cirrhosis is a severe form of liver fibrosis that results in the irreversible replacement of liver
tissue with scar tissue in the liver. Environmental toxicity, infections, metabolic causes, or …

Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS

R Cao, C Cao, X Hu, K Du, J Zhang, M Li, B Li, H Lin… - Phytomedicine, 2023 - Elsevier
Background Kaempferol is a flavonoid derived from the herb, Kaempferia galanga L., in
addition to exhibiting a wide range of pharmacological properties, kaempferol is also an anti …

Cholesterol-mediated seeding of protein corona on DNA nanostructures for targeted delivery of oligonucleotide therapeutics to treat liver fibrosis

KR Kim, J Kim, JH Back, JE Lee, DR Ahn - ACS nano, 2022 - ACS Publications
The protein corona is a protein layer formed on the surface of nanoparticles administered in
vivo and considerably affects the in vivo fate of nanoparticles. Although it is challenging to …

The role of exosomes in inflammatory diseases and tumor-related inflammation

Y Tian, C Cheng, Y Wei, F Yang, G Li - Cells, 2022 - mdpi.com
Inflammation plays a decisive role in inducing tumorigenesis, promoting tumor development,
tumor invasion and migration. The interaction of cancer cells with their surrounding stromal …

New therapeutics for HCC: Does tumor immune microenvironment matter?

A Khanam, S Kottilil - International Journal of Molecular Sciences, 2022 - mdpi.com
The incidence of liver cancer is continuously rising where hepatocellular carcinoma (HCC)
remains the most common form of liver cancer accounting for approximately 80–90% of the …

Mitochondria and the NLRP3 inflammasome in alcoholic and nonalcoholic steatohepatitis

S Torres, P Segalés, C García-Ruiz… - Cells, 2022 - mdpi.com
Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver
disease and two of the most prevalent forms of chronic liver disease. ASH and NASH are …

Protective effect of polyphenols, protein, peptides, and polysaccharides on alcoholic liver disease: A review of research status and molecular mechanisms

W Wang, C Xu, Q Wang, MA Hussain… - Journal of Agricultural …, 2023 - ACS Publications
Alcoholic liver disease (ALD) has emerged as an important public health problem in the
world. The polyphenols, protein, peptides, and polysaccharides have attracted attention for …

The Material World of 3D‐Bioprinted and Microfluidic‐Chip Models of Human Liver Fibrosis

AM Carvalho, R Bansal, CC Barrias… - Advanced …, 2024 - Wiley Online Library
Biomaterials are extensively used to mimic cell–matrix interactions, which are essential for
cell growth, function, and differentiation. This is particularly relevant when developing in vitro …

Collagenase-I decorated co-delivery micelles potentiate extracellular matrix degradation and hepatic stellate cell targeting for liver fibrosis therapy

L Zhou, Q Liang, Y Li, Y Cao, J Li, J Yang, J Liu, J Bi… - Acta Biomaterialia, 2022 - Elsevier
Liver fibrosis is a pathological process of multiple chronic liver diseases progressing to
cirrhosis for which there are currently no effective treatment options. During fibrosis …