The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Multipotent neural progenitor cells (NPCs) undergo self-renewal while producing neurons,
astrocytes, and oligodendrocytes. These processes are controlled by multiple basic helix …

The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …

During brain development, proper neuronal migration and morphogenesis is critical for the
establishment of functional neural circuits. Here we report that srGAP2 negatively regulates …

With the exception of astroglia-like cells in the neurogenic niches of the telencephalic
subependymal or hippocampal subgranular zone, astroglia in all other regions of the adult …

During development of the CNS, neurons and glia are generated in a sequential manner.
The mechanism underlying the later onset of gliogenesis is poorly understood, although the …

The molecular mechanisms specifying the dendritic morphology of different neuronal
subtypes are poorly understood. Here we demonstrate that the bHLH transcription factor …

Motility is a universal property of newly generated neurons. How cell migration is
coordinately regulated with other aspects of neuron production is not well understood. Here …

Pro-neural transcription factors and small molecules can induce the reprogramming of
fibroblasts into functional neurons; however, the immediate-early molecular events that …

Proneural basic helix–loop–helix proteins are key regulators of neurogenesis but their
'proneural'function is not well understood, partly because primary targets have not been …