Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …

Autophagy maintains cellular homeostasis during low energy states. According to the
current understanding, glucose-depleted cells induce autophagy through AMPK, the primary …

Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …