Publisher Summary This chapter summarizes the experimental information on protein
energetics. This field is developing fast and the concept of the energetics of protein structure …

Immune cells and skin and mucosal epithelial cells recognize invasive microbes and other
signs of danger to sound alarms that recruit responder cells and initiate an immediate …

Abstract Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to
microbial infection and danger signals. When activated, they cleave mouse and human …

For unstructured “randomcoil” peptides it has long been recognized that the chemical shift of
the Ca and side-chain carbons of a given residue is largely independent of the nature of …

Segment match modeling uses a data base of highly refined known protein X-ray structures
to build an unknown target structure from its amino acid sequence and the atomic co …

Water molecules inside cavities in proteins constitute integral parts of the structure. We have
sought a quantitative measure of the hydrophilicity of the cavities by calculating energies …

Previous crystallographic analyses of the Kunitz inhibitors from soybean, Erythrina caffra
and wheat, the interleukins-1β and 1α and the acidic and basic fibroblast growth factors …

Members of the fibroblast growth factor (FGF) family of proteins stimulate the proliferation
and differentiation of a variety of cell types through receptor-mediated pathways. The three …

The interleukin-1 (IL-1) family members play an important role in the process of inflammation
and host defense. We describe here the identification and characterization of a novel …

The Kunitz-type trypsin inhibitor from soybean (STI) consists of 181 amino acid residues with
two disulfide bridges. Its crystal structures have been determined in complex with porcine …