Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …

How adhesive interactions between cells generate and maintain animal tissue structure
remains one of the most challenging and long-standing questions in cell and developmental …

Cadherins are the principal adhesion proteins at intercellular junctions and function as the
biochemical Velcro that binds cells together. Besides this mechanical function, cadherin …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …

Junctional structures maintain the integrity of the endothelium. Recent studies have shown
that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals …

The epithelial cadherin (E-cadherin)–catenin complex binds to cytoskeletal components and
regulatory and signaling molecules to form a mature adherens junction (AJ). This dynamic …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

Epithelial cell-cell junctions, organized by adhesion proteins and the underlying actin
cytoskeleton, are considered to be stable structures maintaining the structural integrity of …

Control of the establishment of cell polarity is an essential function in tissue morphogenesis
and renewal that depends on spatial cues provided by the extracellular environment. The …