Chemical insights into the issues of Gd retention in the brain and other tissues upon the administration of Gd‐containing MRI contrast agents

E Gianolio, ED Gregorio, S Aime - European Journal of …, 2019 - Wiley Online Library
Gadolinium bearing contrast agents (GBCA) are commonly used in clinical settings as they
add relevant physiological information to the superb anatomical resolution of the MR …

Gadolinium-doped mesoporous calcium silicate/chitosan scaffolds enhanced bone regeneration ability

F Liao, XY Peng, F Yang, QF Ke, ZH Zhu… - Materials Science and …, 2019 - Elsevier
Chitosan (CTS) and mesoporous calcium silicate (MCS) have been developed for bone
defect healing; however, their bone regeneration capacity still does not satisfy the patients …

Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats

S Bussi, A Coppo, R Celeste, A Fanizzi… - Insights into …, 2020 - Springer
Objectives The purpose of this study was to compare Gd levels in rat tissues after cumulative
exposure to four commercially available macrocyclic gadolinium-based contrast agents …

Does age interfere with gadolinium toxicity and presence in brain and bone tissues?: a comparative gadoterate versus gadodiamide study in juvenile and adult rats

N Fretellier, A Granottier, M Rasschaert… - Investigative …, 2019 - journals.lww.com
Objectives The main objective of the study was to assess the effect of age on target tissue
total gadolinium (Gd) retention after repeated administration of gadodiamide (linear) or …

Effects of gadolinium deposition in the brain on motor or behavioral function: a mouse model

H Akai, K Miyagawa, K Takahashi, A Mochida-Saito… - Radiology, 2021 - pubs.rsna.org
Background Recent studies showing gadolinium deposition in multiple organs have raised
concerns about the safety of gadolinium-based contrast agents (GBCAs). Purpose To …

Uptake of Gadolinium-Based Contrast Agents by Blood Cells During Contrast-Enhanced MRI Examination

N Ruprecht, D Parakkattel, L Hofmann… - Investigative …, 2024 - journals.lww.com
Objectives Gadolinium-based contrast agents (GBCAs) are routinely used in magnetic
resonance imaging (MRI) examinations. However, there is limited knowledge about the …

Mild dissolution/recomplexation strategy for speciation analysis of gadolinium from MR contrast agents in bone tissues by means of HPLC-ICP-MS

L Schlatt, A Köhrer, C Factor, P Robert… - Analytical …, 2021 - ACS Publications
A species-dependent and total gadolinium quantification strategy for the analysis of bone
and bone marrow samples was developed and applied to femurs of rats previously treated …

[HTML][HTML] Elemental Bioimaging of Sheep Bone and Articular Cartilage After Single Application of Gadolinium-Based Contrast Agents

H Richter, C Verlemann, A Jeibmann… - Investigative …, 2024 - journals.lww.com
Background Gadolinium-based contrast agents (GBCAs) are applied to enhance magnetic
resonance imaging. Gadolinium (Gd), a rare earth metal, is used in a chelated form when …

[HTML][HTML] Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration

R Nakamura, Y Takanezawa, Y Ohshiro… - … and Biophysics Reports, 2022 - Elsevier
Gadolinium-based contrast agents (GBCAs) are widely used to improve tissue contrast
during magnetic resonance imaging. Exposure to GBCAs can result in gadolinium …

Analysis of retention of gadolinium by brain, bone, and blood following linear gadolinium‐based contrast agent administration in rats with experimental sepsis

NM Damme, DP Fernandez, LM Wang… - Magnetic …, 2020 - Wiley Online Library
Purpose It is important to identify populations that may be vulnerable to the brain deposition
of gadolinium (Gd) from MRI contrast agents. At intervals from 24 hours to 6 weeks following …