Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the …

The molecular mechanisms of pulmonary fibrosis are poorly understood, although reactive
oxygen species are thought to have an important role. NRF2 is a transcription factor that …

Pulmonary fibrosis, the final result of a large variety of interstitial lung diseases, is
characterized by an aberrant remodeling of extracellular matrix (ECM) with a profound …

Background Reactive oxygen species and tissue remodeling regulators, such as
metalloproteinases (MMPs) and their inhibitors (TIMPs), are thought to be involved in the …

Idiopathic Pulmonary Fibrosis (IPF) is characterized by injury and loss of lung epithelial
cells, accumulation of fibroblasts/myofibroblasts and abnormal remodeling of the lung …

Background Matrix metalloproteinases (MMPs) may have pro and antifibrotic roles within the
lungs, due to its ability to modulate collagen turnover and immune mediators. MMP-8 is a …

Matrix metalloproteinases (MMPs) are part of a superfamily of metal‐requiring proteases that
play important roles in tissue remodeling by breaking down proteins in the extracellular …

Renal fibrosis is a common finding in progressive renal diseases. Matrix metalloproteinases
(MMPs) are involved in epithelial-to-mesenchymal transition (EMT). We investigated the role …

Osteopontin is a multifunctional matricellular protein abundantly expressed during
inflammation and repair. Osteopontin deficiency is associated with abnormal wound repair …

Introduction Arsenic (As) exposure is associated with lung toxicity and we aim to investigate
the effects of arsenic exposure on lung fibrotic changes. Methods Participants (n= 976) …