High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation

C Wittkowske, GC Reilly, D Lacroix… - … in bioengineering and …, 2016 - frontiersin.org
This review describes the role of bone cells and their surrounding matrix in maintaining
bone strength through the process of bone remodeling. Subsequently, this work focusses on …

Design of pressure-driven microfluidic networks using electric circuit analogy

KW Oh, K Lee, B Ahn, EP Furlani - Lab on a Chip, 2012 - pubs.rsc.org
This article reviews the application of electric circuit methods for the analysis of pressure-
driven microfluidic networks with an emphasis on concentration-and flow-dependent …

Microfluidic platforms for mechanobiology

WJ Polacheck, R Li, SGM Uzel, RD Kamm - Lab on a Chip, 2013 - pubs.rsc.org
Mechanotransduction has been a topic of considerable interest since early studies
demonstrated a link between mechanical force and biological response. Until recently …

Hydrodynamics in cell studies

D Huber, A Oskooei, X Casadevall i Solvas… - Chemical …, 2018 - ACS Publications
Hydrodynamic phenomena are ubiquitous in living organisms and can be used to
manipulate cells or emulate physiological microenvironments experienced in vivo …

[HTML][HTML] Development and recent advancement in microfluidics for point of care biosensor applications: A review

P Lakhera, V Chaudhary, B Bhardwaj, P Kumar… - … and Bioelectronics: X, 2022 - Elsevier
Capillaries are small microscopic channels found in nature predominantly. These flow blood
in animals and food, water and nutritions in plants. Mimicking these capillaries scientist …

Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip

MNS de Graaf, A Vivas, DG Kasi, FE van den Hil… - Lab on a Chip, 2023 - pubs.rsc.org
Three-dimensional (3D) blood vessels-on-a-chip (VoC) models integrate the biological
complexity of vessel walls with dynamic microenvironmental cues, such as wall shear stress …

Microfluidic models of physiological or pathological flow shear stress for cell biology, disease modeling and drug development

H Chen, Z Yu, S Bai, H Lu, D Xu, C Chen, D Liu… - TrAC Trends in …, 2019 - Elsevier
Shear stress of physiological flows in the human body plays a critical role in maintaining the
structure and functions of single cells and multicellular organs. Recently, the wide-spreading …

A microfluidic-based multi-shear device for investigating the effects of low fluid-induced stresses on osteoblasts

W Yu, H Qu, G Hu, Q Zhang, K Song, H Guan, T Liu… - PloS one, 2014 - journals.plos.org
Interstitial fluid flow (IFF) within the extracellular matrix (ECM) produces low magnitude
shear stresses on cells. Fluid flow-induced stress (FSS) plays an important role during tissue …

Microfluidic co-culture platform for investigating osteocyte-osteoclast signalling during fluid shear stress mechanostimulation

K Middleton, S Al-Dujaili, X Mei, A Günther… - Journal of biomechanics, 2017 - Elsevier
Bone cells exist in a complex environment where they are constantly exposed to numerous
dynamic biochemical and mechanical stimuli. These stimuli regulate bone cells that are …