The development of new drugs has become challenging as the necessary investments in
time and money have increased while drug approval rates have decreased. A potential …

Recent large-scale genetic approaches such as genome-wide association studies have
allowed the identification of common genetic variations that contribute to risk architectures of …

Whole-genome sequencing is identifying growing numbers of non-coding variants in human
disease studies, but the lack of accurate functional annotations prevents their interpretation …

The vast noncoding portion of the human genome harbors a rich array of functional
elements and disease-causing regulatory variants. Recent high-throughput chromosome …

The human genome hosts several active families of transposable elements (TEs), including
the Alu, LINE-1, and SVA retrotransposons that are mobilized via reverse transcription of …

Whole-exome and whole-genome sequencing have revealed millions of somatic mutations
associated with different human cancers, and the vast majority of them are located outside of …

Long-range regulation by distal enhancers is crucial for many biological processes. The
existing methods for enhancer-target gene prediction often require many genomic features …

Structural variants (SV) are changes in the genomic landscape that can alter gene
expression levels and thus lead to disease development. The most common and best …

MicroRNAs (miRNAs) play important roles in the physiology and development of cancers.
The increase of multidimensional molecular profiles of tumor patients generated by high …

Huge fiscal investments in conjunction with high attrition rates encountered during de novo
drug discovery delay the timelines required for development and entry of novel drug …