Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment

LD Wood, MI Canto, EM Jaffee, DM Simeone - Gastroenterology, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

Early intra-acinar events in pathogenesis of pancreatitis

A Saluja, V Dudeja, R Dawra, RP Sah - Gastroenterology, 2019 - Elsevier
Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy

H Witt, MV Apte, V Keim, JS Wilson - Gastroenterology, 2007 - Elsevier
Chronic pancreatitis (CP) is characterized by progressive pancreatic damage that eventually
results in significant impairment of exocrine as well as endocrine functions of the gland. In …

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

J Rosendahl, H Witt, R Szmola, E Bhatia, B Ózsvári… - Nature …, 2008 - nature.com
Chronic pancreatitis is a persistent inflammatory disease of the pancreas, in which the
digestive protease trypsin has a fundamental pathogenetic role. Here we have analyzed the …

Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis

R Dawra, RP Sah, V Dudeja, L Rishi, R Talukdar… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: The role of trypsinogen activation in the pathogenesis of acute
pancreatitis (AP) has not been clearly established. METHODS: We generated and …

New insights into the pathogenesis of pancreatitis

RP Sah, RK Dawra, AK Saluja - Current opinion in …, 2013 - journals.lww.com
Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …

Familial pancreatic cancer

C Shi, RH Hruban, AP Klein - Archives of pathology & …, 2009 - meridian.allenpress.com
Abstract Context.—Approximately 5% to 10% of individuals with pancreatic cancer report a
history of pancreatic cancer in a close family member. In addition, several known genetic …

[HTML][HTML] Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice

K Liu, J Liu, B Zou, C Li, HJ Zeh, R Kang… - Cellular and molecular …, 2022 - Elsevier
Background & Aims Pancreatitis is characterized by acinar cell death and persistent
inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is …

Mechanisms of alcoholic pancreatitis

MV Apte, RC Pirola, JS Wilson - Journal of gastroenterology …, 2010 - Wiley Online Library
Alcoholic pancreatitis is a major complication of alcohol abuse. The risk of developing
pancreatitis increases with increasing doses of alcohol, suggesting that alcohol exerts dose …

Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y

R Szmola, M Sahin-Tóth - Proceedings of the National …, 2007 - National Acad Sciences
Digestive trypsins undergo proteolytic breakdown during their transit in the human
alimentary tract, which has been assumed to occur through trypsin-mediated cleavages …