Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review

P Mikulska, M Malinowska, M Ignacyk, P Szustowski… - Pharmaceutics, 2023 - mdpi.com
In recent years, there has been a significant surge in reports on the health-promoting
benefits of winter cherry (Withania somnifera), also known as Ashwagandha. Its current …

Withania somnifera (L.) Dunal: Phytochemistry, structure-activity relationship, and anticancer potential

D Tewari, V Chander, A Dhyani, S Sahu, P Gupta… - Phytomedicine, 2022 - Elsevier
Background Ayurveda is a highly recognized, well-documented, and well-accepted
traditional medicine system. This system utilizes many natural products in various forms for …

Role of plant-derived active constituents in cancer treatment and their mechanisms of action

AW Khan, M Farooq, M Haseeb, S Choi - Cells, 2022 - mdpi.com
Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics

G Zhao, C Liu, X Wen, G Luan, L Xie, X Guo - Pharmacology & …, 2021 - Elsevier
Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

S Kumar, SO Mathew, RP Aharwal, HS Tulli… - Pharmaceuticals, 2023 - mdpi.com
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

Anti-inflammatory effects of different dietary antioxidants

A Roy, S Das, I Chatterjee, S Roy… - Plant Antioxidants and …, 2022 - Springer
Chronic inflammation and oxidative damage have been proven as fundamental factors
associated with many systemic diseases, leading to increased morbidity. To deal with this …

CircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC)

Y Wang, Y Wu, S Xie - Bioengineered, 2022 - Taylor & Francis
In recent years, the problem of cancer resistance has become more and more prominent,
seriously affecting treatment efficiency. Circular RNAs (circRNAs) play an important role in …

[HTML][HTML] The roles and targeting options of TRIM family proteins in tumor

Y Zhang, W Zhang, L Zheng, Q Guo - Frontiers in Pharmacology, 2022 - frontiersin.org
Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are
critically implicated in the occurrence and development of tumors. They can function through …

[HTML][HTML] Intricate confrontation: Research progress and application potential of TRIM family proteins in tumor immune escape

J Gu, J Chen, S Xiang, X Zhou, J Li - Journal of Advanced Research, 2023 - Elsevier
Background Tripartite motif (TRIM) family proteins have more than 80 members and are
widely found in various eukaryotic cells. Most TRIM family proteins participate in the …

Molecular targets and mechanisms of anti-cancer effects of withanolides

Z Zhang, Y Yang, Y Xu, Y Liu, H Li, L Chen - Chemico-Biological …, 2023 - Elsevier
Withanolides are a class of natural products with a steroidal lactone structure that exhibit a
broad spectrum of anti-cancer effects. To date, several studies have shown that their …