Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options

W Löscher, H Potschka, SM Sisodiya, A Vezzani - Pharmacological reviews, 2020 - ASPET
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

The epidemiology of drug‐resistant epilepsy: a systematic review and meta‐analysis

L Kalilani, X Sun, B Pelgrims, M Noack‐Rink… - …, 2018 - Wiley Online Library
Objective The definition of drug‐resistant epilepsy (DRE) affects case identification and
treatment, and impacts prevalence or incidence estimates and health burden estimation in …

Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study

Z Chen, MJ Brodie, D Liew, P Kwan - JAMA neurology, 2018 - jamanetwork.com
Importance A study published in 2000 showed that more than one-third of adults with
epilepsy have inadequate control of seizures with antiepileptic drugs (AEDs). This study …

Drug-resistant epilepsy: multiple hypotheses, few answers

F Tang, AMS Hartz, B Bauer - Frontiers in neurology, 2017 - frontiersin.org
Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …

Comorbidities of epilepsy: current concepts and future perspectives

MR Keezer, SM Sisodiya, JW Sander - The Lancet Neurology, 2016 - thelancet.com
The burden of comorbidity in people with epilepsy is high. Several diseases, including
depression, anxiety, dementia, migraine, heart disease, peptic ulcers, and arthritis are up to …

Эпилепсия у детей и взрослых женщин и мужчин

ВА Карлов - 2019 - elibrary.ru
В руководстве представлены результаты 60-летней работы автора в области детской
и взрослой неврологии и эпилептологии. Впервые эпилептология представлена в …

Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023 - thelancet.com
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

Management of psychiatric and neurological comorbidities in epilepsy

AM Kanner - Nature Reviews Neurology, 2016 - nature.com
The treatment of epileptic seizure disorders is not restricted to the achievement of seizure-
freedom, but must also include the management of comorbid medical, neurological …

Epilepsy, antiepileptic drugs, and aggression: an evidence-based review

MJ Brodie, F Besag, AB Ettinger, M Mula, G Gobbi… - Pharmacological …, 2016 - ASPET
Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

Epilepsy, suicidality, and psychiatric disorders: a bidirectional association

DC Hesdorffer, L Ishihara, L Mynepalli… - Annals of …, 2012 - Wiley Online Library
Objective: A study was undertaken to determine whether psychiatric disorders associated
with suicide are more common in incident epilepsy than in matched controls without …