Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways

T Darville - The Journal of infectious diseases, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) results from ascension of sexually transmitted pathogens
from the lower genital tract to the uterus and/or fallopian tubes in women, with potential …

[HTML][HTML] Mucocutaneous IL-17 immunity in mice and humans: host defense vs. excessive inflammation

J Li, JL Casanova, A Puel - Mucosal immunology, 2018 - Elsevier
Abstract Interleukin (IL)-17A is a pro-inflammatory cytokine in mice and humans. It is
recognized as a key factor for the protection of mice against various pathogens, but it also …

Interleukin‐17 family cytokines in protective immunity against infections: role of hematopoietic cell‐derived and non‐hematopoietic cell‐derived interleukin‐17s

G Matsuzaki, M Umemura - Microbiology and immunology, 2018 - Wiley Online Library
Interleukin‐17 family cytokines, consisting of six members, participate in immune response
in infections and autoimmune and inflammatory diseases. The prototype cytokine of the …

Pathogenesis of fallopian tube damage caused by Chlamydia trachomatis infections

LM Hafner - Contraception, 2015 - Elsevier
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease
worldwide resulting in 4–5 million new cases of Chlamydia annually and an estimated 100 …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

[HTML][HTML] Influence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections

A Aiyar, AJ Quayle, LR Buckner… - Frontiers in cellular …, 2014 - frontiersin.org
The natural history of genital Chlamydia trachomatis infections can vary widely; infections
can spontaneously resolve but can also last from months to years, potentially progressing to …

Immunopathogenesis of genital Chlamydia infection: insights from mouse models

J Dockterman, J Coers - Pathogens and Disease, 2021 - academic.oup.com
Chlamydiae are pathogenic intracellular bacteria that cause a wide variety of diseases
throughout the globe, affecting the eye, lung, coronary arteries and female genital tract …

Relationship between female genital tract infections, mucosal interleukin‐17 production and local T helper type 17 cells

L Masson, AL Salkinder, AJ Olivier, LR McKinnon… - …, 2015 - Wiley Online Library
Summary T helper type 17 (Th17) cells play an important role in immunity to fungal and
bacterial pathogens, although their role in the female genital tract, where exposure to these …

[HTML][HTML] The role of infected epithelial cells in Chlamydia-associated fibrosis

LT Caven, RA Carabeo - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Ocular, genital, and anogenital infection by the obligate intracellular pathogen Chlamydia
trachomatis have been consistently associated with scar-forming sequelae. In cases of …

[HTML][HTML] Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge

NDNT Nguyen, AW Olsen, E Lorenzen, P Andersen… - npj Vaccines, 2020 - nature.com
The optimal protective immunity against Chlamydia trachomatis (Ct) is still not fully resolved.
One of the unresolved issues concerns the importance of resident immunity, since a recent …