Emergence and developmental roles of the cerebrospinal fluid system

RM Fame, MK Lehtinen - Developmental cell, 2020 - cell.com
We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …

The immunomodulatory potential role of mesenchymal stem cells in diseases of the central nervous system

RA Rufino, LS Pereira-Rufino, TCS Vissoto… - Neurodegenerative …, 2023 - karger.com
Introduction: Several studies indicate the role of mesenchymal stem cells (MSCs) as an
important tool in regenerative medicine associated with injuries that affect the central …

Mesenchymal stem cell-conditioned medium improves mitochondrial dysfunction and suppresses apoptosis in okadaic acid-treated SH-SY5Y cells by extracellular …

Z Zhang, H Sheng, LI Liao, C Xu… - Journal of …, 2020 - content.iospress.com
Background: Mesenchymal stem cells-conditioned medium (MSC-CM) provides a promising
cell-free therapy for Alzheimer's disease (AD) mainly due to the paracrine of MSCs, but the …

Mechanical filtration of the cerebrospinal fluid: procedures, systems, and applications

M Menéndez González - Expert Review of Medical Devices, 2023 - Taylor & Francis
Introduction Mechanical methods aimed at the filtration of the cerebrospinal fluid (CSF) are a
group of therapies that have been proposed to treat neurological conditions where …

Cerebrospinal fluid (CSF) exchange therapy with artificial CSF enriched with mesenchymal stem cell secretions ameliorates cognitive deficits and brain pathology in …

S Benhamron, K Nitzan, M Valitsky… - Journal of …, 2020 - content.iospress.com
Background: The high complexity of neurodegenerative diseases, including Alzheimer's
disease (AD), and the lack of effective treatments point to the need for a broader therapeutic …

Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development

K Radoszkiewicz, A Bzinkowska… - Frontiers in …, 2024 - frontiersin.org
Neural stem cells (NSCs) hold a very significant promise as candidates for cell therapy due
to their robust neuroprotective and regenerative properties. Preclinical studies using NSCs …

Cerebrospinal fluid flushing as a means of neuroprotection

MA Dufwenberg, AR Garfinkel, M Greenhill… - Frontiers in …, 2023 - frontiersin.org
Central nervous system (CNS) injury or disease states are often difficult to treat due to the
closed system of the dura mater/blood-brain barrier and the bony skull and vertebrae. The …

Effect of Multiple Sclerosis Cerebrospinal Fluid and Oligodendroglia Cell Line Environment on Human Wharton's Jelly Mesenchymal Stem Cells Secretome

K Salwierak-Głośna, P Piątek, M Domowicz… - International Journal of …, 2022 - mdpi.com
Multiple sclerosis (MS) is a neurological disorder of autoimmune aetiology. Experimental
therapies with the use of mesenchymal stem cells (MSCs) have emerged as a response to …

Mezenkimal kök hücre üretiminde in vitro temelli metabolomik ve analizler

T Karaağaç Akyol - 2020 - acikbilim.yok.gov.tr
Çalışmamızda MKH'ler FBS, PL, PPP ve KİP varlığında ve ayrıca LPS varlığında
inflamatuvar ortama maruz bırakılarak farklı eklentilerin etkisi araştırılmıştır. Eklentilerinin …