Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

The renin-angiotensin system (RAS) is one of the oldest hormone systems in vertebrate
phylogeny. RAS was initially related to regulation of blood pressure and sodium and water …

ACE2 plays a pivotal role in the balance between the pro-oxidative pro-inflammatory and the
anti-oxidative anti-inflammatory arms of the renin-angiotensin system. Furthermore, ACE2 is …

G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved
and clinical prescribed drugs and represent the largest and most structurally diverse family …

Mesangial cells stimulated with high glucose (HG) exhibit increased intracellular
angiotensin II (AngII) synthesis that is correlated with the upregulation of AngII target genes …

Cardiomyopathy and fibrosis are the main causes of heart failure in diabetes patients. For
therapeutic purposes, a delivery system is required to enhance antidiabetic drug efficacy …

Obesity is often associated with high systemic and local renin–angiotensin system (RAS)
activity in adipose tissue. Adipose‐derived mesenchymal stem/stromal cells (ADSC s) …

Connexin 43 (Cx43) is expressed in kidney tissue where it forms hemichannels and gap
junction channels. However, the possible functional relationship between these membrane …

The renin-angiotensin system (RAS) is implicated in the maintenance of blood pressure and
in many other biological processes including tumorigenesis and metastasis formation …

The fibrogenic process plays a significant pathophysiological role in the progression of
chronic kidney disease. Inhibition of the renin-angiotensin system (RAS) is one strategy to …