In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …

Diverse cell types in tissues have distinct gene expression programs, chromatin states, and
nuclear architectures. To correlate such multimodal information across thousands of single …

Abstract Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive
heterochromatin, which is crucial for chromosome maintenance and transcriptional …

Gene expression in mammalian cells depends on the epigenetic status of the chromatin,
including DNA methylation, histone modifications, promoter–enhancer interactions, and …

Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder
characterized by regressive loss of neurodevelopmental milestones and acquired …

Mutations in the X-linked gene MECP2 cause Rett syndrome, a progressive neurological
disorder in which children develop normally for the first one or two years of life before …

Rett syndrome (RTT) is a debilitating neurological disorder caused by mutations in the gene
encoding the transcription factor Methyl CpG Binding Protein 2 (MECP2). A distinct disorder …

We introduce a computational model to simulate chromatin structure and dynamics. Starting
from one-dimensional genomics and epigenomics data that are available for hundreds of …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …