The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …

Chronic metabolic disease is considered by a high concentration of glucose in the blood
consequent from imperfections in insulin secretion or insulin action. Currently, it is rapidly …

BACKGROUND፡ Genetic variants that affect insulin signaling play an important role in
insulin resistance (IR) in type 2 diabetes mellitus (T2DM). This study aimed to evaluate …

Insulin resistance (IR), a pathological condition of type 2 diabetes mellitus (T2DM) is
characterized by an inability of body's tissue to respond the secreted or administered insulin …

Background/aim: Abdominal obesity and associated metabolic consequences are a
burgeoning problem in Asian Indians and studying their genetic predisposition is important …

Aim and objective The aim of the study was to investigate the relationships between insulin
receptor substrate (IRS) 1 (Gly972Arg) and IRS2 (Gly1057Asp) genes with obstructive sleep …

Background Previous studies reported conflicting results regarding association of insulin
receptor substrate 1 (IRS1) gene variation with type 2 diabetes (T2D) and insulin resistance …

Background: Type 2 Diabetes Mellitus (T2DM) is a worldwide disorder as the most important
challenges of health-care systems. Controlling the normal glycaemia greatly profit long-term …

The objective of the study is to assess the association between rs1801278 and rs2943641 of
insulin receptor substrate 1 gene (IRS1) and the susceptibility to type 2 diabetes. A literature …

The clinical response to sulphonylurea, an oral antidiabetic agent often used in combination
with metformin to control blood glucose in type 2 diabetes (T2DM) patients, has been widely …