Mismatch repair stabilizes the cellular genome by correcting DNA replication errors and by
blocking recombination events between divergent DNA sequences. The reaction …

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder
characterized by the occurrence within a family of multiple cases of colorectal cancer in the …

Microsatellite instability is an important characteristic of many tumor types1–8 especially
those associated with hereditary non–polyposis colorectal carcinoma (HNPCC) syndrome6 …

To investigate the role of the presumed DNA mismatch repair (MMR) gene Msh2 in genome
stability and tumorigenesis, we have generated cells and mice that are deficient for the …

Microsatellite instability (MSI) has been detected in endometrial carcinomas occurring in
women affected by hereditary nonpolyposis colorectal carcinoma (HNPCC) as well as in …

Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary
nonpolyposis colon cancer. To understand the role of MLH1 in normal growth and …

Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to
the bacterial MutS protein. In this study the role of MSH2, MSH3, and MSH6 in mismatch …

A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding
proteins that interact with MSH2. One gene was found to encode a homologue of …

This article is the first in a series of seven that will provide an overview of central concepts
and topical issues in modern genetic epidemiology. In this article, we provide an overall …

Mice carrying a null mutation in the mismatch repair gene Msh6 were generated by gene
targeting. Cells that were homozygous for the mutation did not produce any detectable …