Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …
permeate ions across the cell membrane in response to changes in membrane potential …
Generation of FeIV=O and its Contribution to Fenton‐Like Reactions on a Single‐Atom Iron−N−C Catalyst
Generating FeIV= O on single‐atom catalysts by Fenton‐like reaction has been established
for water treatment; however, the FeIV= O generation pathway and oxidation behavior …
for water treatment; however, the FeIV= O generation pathway and oxidation behavior …
Site engineering of covalent organic frameworks for regulating peroxymonosulfate activation to generate singlet oxygen with 100% selectivity
Z Weng, Y Lin, S Guo, X Zhang, Q Guo… - Angewandte …, 2023 - Wiley Online Library
Abstract Singlet oxygen (1O2) is an excellent reactive oxygen species (ROSs) for the
selective conversion of organic matter, especially in advanced oxidation processes (AOPs) …
selective conversion of organic matter, especially in advanced oxidation processes (AOPs) …
Enhanced Interfacial Electron Transfer by Asymmetric Cu‐Ov‐In Sites on In2O3 for Efficient Peroxymonosulfate Activation
Enhancing the peroxymonosulfate (PMS) activation efficiency to generate more radicals is
vital to promote the Fenton‐like reaction activity, however, how to promote the PMS …
vital to promote the Fenton‐like reaction activity, however, how to promote the PMS …
Structural mapping of Nav1.7 antagonists
Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …
Cannabidiol inhibits Nav channels through two distinct binding sites
Cannabidiol (CBD), a major non-psychoactive phytocannabinoid in cannabis, is an effective
treatment for some forms of epilepsy and pain. At high concentrations, CBD interacts with a …
treatment for some forms of epilepsy and pain. At high concentrations, CBD interacts with a …
Cryo-EM structure of human voltage-gated sodium channel Nav1.6
Voltage-gated sodium channel Nav1. 6 plays a crucial role in neuronal firing in the central
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …
Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1.7
G Huang, Q Wu, Z Li, X Jin, X Huang… - Proceedings of the …, 2022 - National Acad Sciences
Voltage-gated sodium (Nav) channel Nav1. 7 has been targeted for the development of
nonaddictive pain killers. Structures of Nav1. 7 in distinct functional states will offer an …
nonaddictive pain killers. Structures of Nav1. 7 in distinct functional states will offer an …
A structural atlas of druggable sites on Nav channels
Z Li, Q Wu, N Yan - Channels, 2024 - Taylor & Francis
Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and
propagating action potentials. Consistent with their physiological significance, dysfunction …
propagating action potentials. Consistent with their physiological significance, dysfunction …
Dual-pocket inhibition of Nav channels by the antiepileptic drug lamotrigine
Voltage-gated sodium (Nav) channels govern membrane excitability, thus setting the
foundation for various physiological and neuronal processes. Nav channels serve as the …
foundation for various physiological and neuronal processes. Nav channels serve as the …