Description Proton pump inhibitors (PPIs) are among the most commonly used medications
in the world. Developed for the treatment and prevention of acid-mediated upper …

In early December 2019, a series of pneumonia cases was reported in Wuhan, China
resulting from a novel coronavirus infection designated as severe acute respiratory …

1 ESGE recommends in patients with acute upper gastrointestinal hemorrhage (UGIH) the
use of the Glasgow–Blatchford Score (GBS) for pre-endoscopy risk stratification. Patients …

We performed systematic reviews addressing predefined clinical questions to develop
recommendations with the GRADE approach regarding management of patients with overt …

Background It is recommended that patients with acute upper gastrointestinal bleeding
undergo endoscopy within 24 hours after gastroenterologic consultation. The role of …

Objectives Existing scores are not accurate at predicting mortality in upper (UGIB) and lower
(LGIB) gastrointestinal bleeding. We aimed to develop and validate a new pre-endoscopy …

Description The purpose of this American Gastroenterological Association (AGA) Institute
Clinical Practice Update is to review the available evidence and best practice advice …

Gastrointestinal tract perforation is a full-thickness injury that causes bleeding and fatal
infection of the peritoneum. This condition worsens in an acidic gastric environment which …

1 Lau JY, Barkun A, Fan DM, Kuipers EJ, Yang YS, Chan FK. Challenges in the
management of acute peptic ulcer bleeding. Lancet 2013; 381: 2033–43. 2 Barkun AN …

Objective While it is recommended that patients presenting with acute upper gastrointestinal
bleeding (AUGIB) should receive endoscopic intervention within 24 hours, the optimal timing …