The melanocortin pathway and control of appetite-progress and therapeutic implications

G Baldini, KD Phelan - Journal of Endocrinology, 2019 - joe.bioscientifica.com
The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

The melanocortin system behind the dysfunctional eating behaviors

E Micioni Di Bonaventura, L Botticelli, D Tomassoni… - Nutrients, 2020 - mdpi.com
The dysfunction of melanocortin signaling has been associated with obesity, given the
important role in the regulation of energy homeostasis, food intake, satiety and body weight …

The central melanocortin system as a treatment target for obesity and diabetes: A brief overview

RK Goit, AW Taylor, ACY Lo - European journal of pharmacology, 2022 - Elsevier
The melanocortins are derived from proopiomelanocortin (POMC) and include three forms of
melanocyte-stimulating hormone (α-, β-, γ-, MSH) and adrenocorticotropic hormone. α-MSH …

Organization of neural systems expressing melanocortin‐3 receptors in the mouse brain: Evidence for sexual dimorphism

MN Bedenbaugh, SC Brener… - Journal of …, 2022 - Wiley Online Library
The central melanocortin system is fundamentally important for controlling food intake and
energy homeostasis. Melanocortin‐3 receptor (MC3R) is one of two major receptors of the …

[HTML][HTML] Polymorphisms and mutations in the melanocortin-3 receptor and their relation to human obesity

AP Demidowich, JY Jun, JA Yanovski - Biochimica et Biophysica Acta (BBA …, 2017 - Elsevier
Inactivating mutations in the melanocortin 3 receptor (Mc3r) have been described as
causing obesity in mice, but the physiologic effects of MC3R mutations in humans have …

A life without hunger: the ups (and downs) to modulating melanocortin-3 receptor signaling

AA Butler, C Girardet, M Mavrikaki… - Frontiers in …, 2017 - frontiersin.org
Melanocortin neurons conserve body mass in hyper-or hypo-caloric conditions by conveying
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …

Alpha-melanocyte-stimulating hormone-mediated appetite regulation in the central nervous system

Q Wu, J Chen, T Hua, J Cai - Neuroendocrinology, 2023 - karger.com
Understanding the complex action mechanism of appetite regulation peptides can
significantly impact therapeutic options in the treatment of obesity and other metabolic …

[HTML][HTML] Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards

AI Dunigan, AG Roseberry - Addiction neuroscience, 2022 - Elsevier
The mesolimbic dopamine system is the primary neural circuit mediating motivation,
reinforcement, and reward-related behavior. The activity of this system and multiple …

Overexpression of miR-9 in the nucleus accumbens increases oxycodone self-administration

M Mavrikaki, E Anastasiadou… - International Journal …, 2019 - academic.oup.com
Background There is an urgent need to identify factors that increase vulnerability to opioid
addiction to help stem the opioid epidemic and develop more efficient …

[HTML][HTML] VTA MC3R neurons control feeding in an activity-and sex-dependent manner in mice

AI Dunigan, DP Olson, AG Roseberry - Neuropharmacology, 2021 - Elsevier
Increasing evidence indicates that the melanocortin and mesolimbic dopamine (DA)
systems interact to regulate feeding and body weight. Because melanocortin-3 receptors …