In most species, the centromere is comprised of repetitive DNA sequences, which rapidly
evolve. Paradoxically, centromeres fulfill an essential function during mitosis, as they are the …

The regulation of chromatin biology ultimately depends on the manipulation of its smallest
subunit, the nucleosome. The proteins that bind and operate on the nucleosome do so …

Mechanical extracellular signals elicit chromatin remodeling via the mechanotransduction
pathway, thus determining cellular function. However, the reverse pathway is an open …

Metaphase chromosomes in which both polynucleotides and proteins are condensed with
hierarchies are closely related to life phenomena such as cell division, cancer development …

Chromatin is the epigenomic platform for diverse nuclear processes such as DNA repair,
replication, transcription, telomere, and centromere function. In cancer cells, mutations in key …

The interplay between transcription factors, chromatin remodelers, 3-D organization, and
mechanical properties of the chromatin fiber controls genome function in eukaryotes …

The base unit of DNA packaging in eukaryotes, the nucleosome, is adaptively modified for
epigenetic control. Given the vast chemical space of chromatin and complexity of signaling …