NRF2 regulation processes as a source of potential drug targets against neurodegenerative diseases
Á Cores, M Piquero, M Villacampa, R León… - Biomolecules, 2020 - mdpi.com
NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …
Protective effects on the retina after ranibizumab treatment in an ischemia model
SC Joachim, M Renner, J Reinhard, C Theiss, C May… - PloS one, 2017 - journals.plos.org
Retinal ischemia is common in eye disorders, like diabetic retinopathy or retinal vascular
occlusion. The goal of this study was to evaluate the potential protective effects of an …
occlusion. The goal of this study was to evaluate the potential protective effects of an …
Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice
H Ueda, H Neyama, K Sasaki, C Miyama… - Neurobiology of Pain, 2019 - Elsevier
We developed a mouse model for central post-stroke pain (CPSP), a centrally-originated
neuropathic pain (NeuP). In this mode, mice were first injected with Rose Bengal, followed …
neuropathic pain (NeuP). In this mode, mice were first injected with Rose Bengal, followed …
Critical functionality effects from storage temperature on human induced pluripotent stem cell-derived retinal pigment epithelium cell suspensions
Human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (hiPSC-
RPE) cells suspension have the potential for regenerative treatment. However, practical …
RPE) cells suspension have the potential for regenerative treatment. However, practical …
Modeling of Retina and Optic Nerve Ischemia–Reperfusion Injury through Hypoxia–Reoxygenation in Human Induced Pluripotent Stem Cell-Derived Retinal Ganglion …
T Yoshida, T Yokoi, T Tanaka, E Matsuzaka, Y Saida… - Cells, 2024 - mdpi.com
Retinal ganglion cells (RGCs) are specialized projection neurons that constitute part of the
retina, and the death of RGCs causes various eye diseases, but the mechanism of RGC …
retina, and the death of RGCs causes various eye diseases, but the mechanism of RGC …
[HTML][HTML] Higenamine alleviates cerebral ischemia-reperfusion injury in rats
X Wang, X Li, W Jingfen, D Fei, P Mei - Frontiers in Bioscience …, 2019 - imrpress.com
Cerebral ischemia reperfusion (I/R) injury is associated with a high incidence of neurological
morbidity and mortality worldwide. Higenamine has anti-inflammatory, anti-oxidative and …
morbidity and mortality worldwide. Higenamine has anti-inflammatory, anti-oxidative and …
Prothymosin alpha and its mimetic hexapeptide improve delayed tissue plasminogen activator‐induced brain damage following cerebral ischemia
SK Halder, H Matsunaga, H Ueda - Journal of Neurochemistry, 2020 - Wiley Online Library
Tissue plasminogen activator (tPA) administration beyond 4.5 h of stroke symptoms is
beneficial for patients but has an increased risk of cerebral hemorrhage. Thus, increasing …
beneficial for patients but has an increased risk of cerebral hemorrhage. Thus, increasing …
[HTML][HTML] Experimental evidence for the involvement of F0/F1 ATPase and subsequent P2Y12 receptor activation in prothymosin alpha-induced protection of retinal …
SK Halder, H Matsunaga, H Ueda - Journal of Pharmacological Sciences, 2020 - Elsevier
The inhibition of retinal ischemia-induced damage by post-ischemic prothymosin alpha
(ProTα) was not affected in toll-like receptor 4 knockout (TLR4−/−) mice but blocked by the …
(ProTα) was not affected in toll-like receptor 4 knockout (TLR4−/−) mice but blocked by the …
Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral …
K Sasaki, SK Halder, H Matsunaga, H Ueda - Peptides, 2020 - Elsevier
Prothymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits
cerebral or retinal ischemia-induced behavioral, electrophysiological and histological …
cerebral or retinal ischemia-induced behavioral, electrophysiological and histological …
[HTML][HTML] Lotus seedpod proanthocyanidins protect against light-induced retinal damage via antioxidative stress, anti-apoptosis, and neuroprotective effects
J Wang, T Yu, L Sheng, H Zhang, F Chen… - … Medical Journal of …, 2021 - ncbi.nlm.nih.gov
Background Over-exposure to visible white light can cause retinal damage. Lotus seedpod
proanthocyanidins (LSPCs) possess a variety of biological activities, including potent …
proanthocyanidins (LSPCs) possess a variety of biological activities, including potent …