The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
JR Inigo, D Chandra - Journal of hematology & oncology, 2022 - Springer
Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …
Hypoxia-inducible factors and the regulation of lipid metabolism
Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …
Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells
Abstract Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor essential for
cancer cell survival. The reprogramming of lipid metabolism has emerged as a hallmark of …
cancer cell survival. The reprogramming of lipid metabolism has emerged as a hallmark of …
Regulatory mechanisms of hypoxia‐inducible factor 1 activity: Two decades of knowledge
Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …
Transcriptional response to hypoxia: the role of HIF-1-associated co-regulators
The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia
by regulating the expression of many genes involved in adaptive processes that allow cell …
by regulating the expression of many genes involved in adaptive processes that allow cell …
The role of hypoxia-inducible factor post-translational modifications in regulating its localisation, stability, and activity
A Albanese, LA Daly, D Mennerich… - International journal of …, 2020 - mdpi.com
The hypoxia signalling pathway enables adaptation of cells to decreased oxygen
availability. When oxygen becomes limiting, the central transcription factors of the pathway …
availability. When oxygen becomes limiting, the central transcription factors of the pathway …
Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer–A comprehensive review from chemotherapy to immunotherapy
Breast cancer is the most frequently occurring cancer in women. Chemotherapy in
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …
Hypoxia-inducible factors (HIFs) and phosphorylation: impact on stability, localization, and transactivity
T Kietzmann, D Mennerich, EY Dimova - Frontiers in cell and …, 2016 - frontiersin.org
The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the
mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia …
mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia …
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
JD Webb, ML Coleman, CW Pugh - Cellular and molecular life sciences, 2009 - Springer
This article outlines the need for a homeostatic response to alterations in cellular
oxygenation. It describes work on erythropoietin control that led to the discovery of the …
oxygenation. It describes work on erythropoietin control that led to the discovery of the …
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Adaptation to hypoxia involves hypoxia-inducible transcription factors (HIFs) and requires
reprogramming of cellular metabolism that is essential during both physiological and …
reprogramming of cellular metabolism that is essential during both physiological and …