Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Increasing evidence suggests that ion channels and pumps not only regulate membrane
potential, ion homeostasis, and electric signaling in excitable cells but also play important …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Notch signaling is an evolutionarily conserved pathway that regulates important biological
processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation …

Hypoxia promotes the expansion of non-neoplastic stem and precursor cell populations in
the normal brain, and is common in malignant brain tumors. We examined the effects of …

Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Abstract Background: Transient Receptor Potential (TRP) channels are expressed in many
solid tumors. However, their expression in breast cancer remains largely unknown. Here, we …

Intracellular Ca 2+ is one of the crucial signalings that modulate various cellular functions.
The dysregulation of Ca 2+ homeostasis has been suggested as an important event in …