[HTML][HTML] Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes

M Michailidis, D Moraitou, DA Tata, K Kalinderi… - International journal of …, 2022 - mdpi.com
Globally, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD)
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …

[HTML][HTML] Bioactive compounds of edible fruits with their anti-aging properties: A comprehensive review to prolong human life

R Dhalaria, R Verma, D Kumar, S Puri, A Tapwal… - Antioxidants, 2020 - mdpi.com
Aging is a complicated biological process in which functional and structural alterations in a
living organism take place over time. Reactive oxygen species is one of the main factors …

Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease

G Verdile, KN Keane, VF Cruzat, S Medic… - Mediators of …, 2015 - Wiley Online Library
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

Promising health benefits of the strawberry: a focus on clinical studies

S Afrin, M Gasparrini… - Journal of agricultural …, 2016 - ACS Publications
The potential health benefits associated with dietary intake of fruits have attracted increasing
interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive …

Brain metabolic dysfunction at the core of Alzheimer's disease

SM de la Monte, M Tong - Biochemical pharmacology, 2014 - Elsevier
Growing evidence supports the concept that Alzheimer's disease (AD) is fundamentally a
metabolic disease with molecular and biochemical features that correspond with diabetes …

Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism

JT Morgan, G Chana, CA Pardo, C Achim… - Biological …, 2010 - Elsevier
BACKGROUND: In the neurodevelopmental disorder autism, several neuroimmune
abnormalities have been reported. However, it is unknown whether microglial somal volume …

Fruit polyphenols: A review of anti-inflammatory effects in humans

SV Joseph, I Edirisinghe… - Critical reviews in food …, 2016 - Taylor & Francis
Underlying etiological factors in the development of obesity-related chronic diseases are
long-term imbalances of oxidative and inflammatory stress leading to tissue dysfunction …

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

SM de la Monte - Current Alzheimer Research, 2012 - ingentaconnect.com
Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus

G Mushtaq, NH Greig, JA Khan… - CNS & Neurological …, 2014 - ingentaconnect.com
Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …

The role of type 2 diabetes in neurodegeneration

G Verdile, SJ Fuller, RN Martins - Neurobiology of disease, 2015 - Elsevier
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …