Background Depressive disorders are common in children and adolescents.
Antidepressants, psychotherapies, and their combination are often used in routine clinical …

Background Available evidence on the comparative efficacy and acceptability of
psychotherapies for post-traumatic stress disorder (PTSD) in children and adolescents …

Background Valid assessment of drug efficacy and safety requires an evidence base free of
reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval …

Irritable bowel syndrome (IBS) is a common disorder requiring complex, multidisciplinary
management. Antidepressants are commonly used and recommended in guidelines for the …

Vibration of effect in more than 16 000 pooled analyses of individual participant data from 12
randomised controlled trials comparing canagliflozin and placebo for type 2 diabetes mellitus …

Research institutions' research culture is increasingly recognized as a central driver of
research integrity. Institutions are urged to develop research integrity promotion plans to …

RESUMO Os Problemas de Saúde Mental (SM) e o uso indiscriminado de psicofármacos
são problemas de grande relevância para a Atenção Primária à Saúde (APS) e a saúde …

Background. In recent years, the veracity of scientific findings has come under intense
scrutiny in what has been called the “replication crisis”(sometimes called the “reproducibility …

Mental Health (MH) issues and the indiscriminate use of psychotropic drugs are a great deal
of a problem for the Primary Health Care (PHC) and public health. The aim of this article is to …

The idea behind both the Appropriate Education Act (in Dutch:“Passend Onderwijs”) and the
Youth Act is that more children receive regular education, as well as help and support …