Accumulation of reactive oxygen species (ROS) can induce both protein tyrosine nitration
and endothelial dysfunction in atherosclerosis. Endothelial dysfunction refers to impaired …

Renovascular hypertension is one of the most relevant causes of secondary hypertension,
mostly caused by atherosclerotic renovascular stenosis or fibromuscular dysplasia. The …

Objective Experimental evidence has shown potential cardioprotective actions of
phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in …

Introduction: Hypertension is a leading cause of morbidity and mortality worldwide. A major
pathophysiological factor contributing to hypertension is reduced nitric oxide (NO) …

Hypertension is a common disease that includes oxidative stress as a major feature, and
oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular …

Background/Aims: Icariside II (ICS II) is an active component from Epimedium brevicornum,
a Chinese medicine extensively used in China. Our previous study has proved that ICS II …

Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular
risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine …

Background Oxidative stress and DNA damage have been implicated in the pathogenesis of
renovascular hypertension induced by renal artery stenosis in the two-kidney, one-clip …

Lead (Pb) reduces NO bioavailability, impairs the antioxidant system, and increases the
generation of reactive oxygen species (ROS). Pb‐induced oxidative stress may be …

Chronic arsenic exposure has been linked to elevated blood pressure and cardiovascular
diseases, while statins reduce the incidence of cardiovascular disease predominantly by …