Discerning the chemistry in individual organelles with small‐molecule fluorescent probes
Principle has it that even the most advanced super‐resolution microscope would be futile in
providing biological insight into subcellular matrices without well‐designed fluorescent …
providing biological insight into subcellular matrices without well‐designed fluorescent …
The lysosome as an imperative regulator of autophagy and cell death
KK Mahapatra, SR Mishra, BP Behera, S Patil… - Cellular and Molecular …, 2021 - Springer
Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages
J Lv, Z Wang, Y Qu, H Zhu, Q Zhu, W Tong, L Bao, Q Lv… - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where
abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion …
abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion …
Targeting the lysosome in cancer
S Piao, RK Amaravadi - Annals of the New York Academy of …, 2016 - Wiley Online Library
Lysosomes are membrane‐bound intracellular organelles that receive macromolecules
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …
Lysosomes: fusion and function
Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …
The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
A Panariti, G Miserocchi, I Rivolta - Nanotechnology, science and …, 2012 - Taylor & Francis
Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They
have unique physicochemical properties, and have emerged as important players in current …
have unique physicochemical properties, and have emerged as important players in current …
Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
K Denzer, MJ Kleijmeer, HFG Heijnen… - Journal of cell …, 2000 - journals.biologists.com
Exosomes are small membrane vesicles that are secreted by a multitude of cell types as a
consequence of fusion of multivesicular late endosomes/lysosomes with the plasma …
consequence of fusion of multivesicular late endosomes/lysosomes with the plasma …
pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates
Titratable polyanions, and more particularly polymers bearing carboxylate groups, have
been used in recent years to produce a variety of pH-sensitive colloids. These polymers …
been used in recent years to produce a variety of pH-sensitive colloids. These polymers …
Autophagy, amyloidogenesis and Alzheimer disease
RA Nixon - Journal of cell science, 2007 - journals.biologists.com
Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for
degrading normal and aggregated proteins, particularly under stress or injury conditions …
degrading normal and aggregated proteins, particularly under stress or injury conditions …
Phagosome maturation: going through the acid test
JM Kinchen, KS Ravichandran - Nature reviews Molecular cell biology, 2008 - nature.com
Phagosome maturation is the process by which internalized particles (such as bacteria and
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …