Discerning the chemistry in individual organelles with small‐molecule fluorescent probes

W Xu, Z Zeng, JH Jiang, YT Chang… - Angewandte Chemie …, 2016 - Wiley Online Library
Principle has it that even the most advanced super‐resolution microscope would be futile in
providing biological insight into subcellular matrices without well‐designed fluorescent …

The lysosome as an imperative regulator of autophagy and cell death

KK Mahapatra, SR Mishra, BP Behera, S Patil… - Cellular and Molecular …, 2021 - Springer
Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

J Lv, Z Wang, Y Qu, H Zhu, Q Zhu, W Tong, L Bao, Q Lv… - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where
abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion …

Targeting the lysosome in cancer

S Piao, RK Amaravadi - Annals of the New York Academy of …, 2016 - Wiley Online Library
Lysosomes are membrane‐bound intracellular organelles that receive macromolecules
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …

Lysosomes: fusion and function

JP Luzio, PR Pryor, NA Bright - Nature reviews Molecular cell biology, 2007 - nature.com
Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …

The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

A Panariti, G Miserocchi, I Rivolta - Nanotechnology, science and …, 2012 - Taylor & Francis
Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They
have unique physicochemical properties, and have emerged as important players in current …

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device

K Denzer, MJ Kleijmeer, HFG Heijnen… - Journal of cell …, 2000 - journals.biologists.com
Exosomes are small membrane vesicles that are secreted by a multitude of cell types as a
consequence of fusion of multivesicular late endosomes/lysosomes with the plasma …

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

AE Felber, MH Dufresne, JC Leroux - Advanced drug delivery reviews, 2012 - Elsevier
Titratable polyanions, and more particularly polymers bearing carboxylate groups, have
been used in recent years to produce a variety of pH-sensitive colloids. These polymers …

Autophagy, amyloidogenesis and Alzheimer disease

RA Nixon - Journal of cell science, 2007 - journals.biologists.com
Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for
degrading normal and aggregated proteins, particularly under stress or injury conditions …

Phagosome maturation: going through the acid test

JM Kinchen, KS Ravichandran - Nature reviews Molecular cell biology, 2008 - nature.com
Phagosome maturation is the process by which internalized particles (such as bacteria and
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …