Parkinson's disease is a progressive neurological disorder, characterized by prominent
movement dysfunction. The past two decades have seen a rapid expansion of our …

GCH1 gene provides directions for the synthesis of GTP cyclohydrolase 1 which regulates
the formation of Tetrahydrobiopterin (BH4). BH4 is a crucial cofactor for essential …

Abstract Background Hyperhomocysteinemia (HHcy) is an independent risk factor for
cardiovascular diseases (CVDs). Stachydrine (STA) is an active component in Chinese …

Graphical Abstract Generation of nitric oxide (NO) by the nitric oxide synthase (NOS)
enzymes plays multiple signalling roles in every organ system, with crucial roles in the …

Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) catalyzes the conversion of GTP
into dihydroneopterin triphosphate (DHNP). DHNP is the first intermediate of the folate de …

The GTP cyclohydrolase 1 enzyme (GTPCH1) is the rate-limiting enzyme of the
tetrahydrobiopterin (BH4) biosynthetic pathway. Physiologically, BH4 plays a crucial role as …

Our ability to genetically manipulate microbial systems is often hampered by the availability
of genetic tools. Thus, there is a need for the continued expansion of our molecular tool box …

Abstract GTP Cyclohydrolase I (GCH1) catalyses the conversion of guanosine triphosphate
(GTP) to dihydroneopterin triphosphate (H2NTP), the initiating step in the biosynthesis of …

The development of tool compounds for the study of the tetrahydrobiopterin (BH4) metabolic
network perturbation is of interest especially in the case of oxidative and nitrosative stress …