Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to
endogenous hazard signals and metabolites in the circulatory system. The senescence and …

Cellular senescence is characteristic of the development and progression of multiple age-
associated diseases. Accumulation of senescent cells in the heart contributes to various age …

Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion is now
standard therapy, pathological remodelling leading to heart failure remains a clinical …

ABSTRACT Elabela (ELA), Apela or Toddler peptide is a hormone peptide belonging to the
adipokine group and a component of apelinergic system, discovered in 2013-2014. Given its …

As the global demographic landscape continues to shift towards an aged population, so
does the medical and socioeconomic burden of cardiovascular diseases. Indeed, ageing is …

Cardiac fibrosis is a significant contributor to heart failure and is characterized by abnormal
ECM deposition and impaired contractile function. We have previously developed a model …

Cardiovascular diseases (CVDs), a group of disorders affecting the heart or blood vessels,
are the primary cause of death worldwide, with an immense impact on patient quality of life …

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …

Cellular senescence refers to the permanent and irreversible cessation of the cell cycle.
Recently, it has gained significant interest as a promising target for preventing …