Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation
K Pierzynowska, M Podlacha, L Gaffke, E Rintz… - Autophagy, 2024 - Taylor & Francis
Huntington disease (HD) is a neurodegenerative disorder caused by a mutation in the HTT
gene. The expansion of CAG triplets leads to the appearance of misfolded HTT (huntingtin) …
gene. The expansion of CAG triplets leads to the appearance of misfolded HTT (huntingtin) …
The past and present of Drosophila models of traumatic brain injury
P Aggarwal, D Thapliyal, S Sarkar - Journal of Neuroscience Methods, 2022 - Elsevier
Traumatic brain injuries are highly recognized as one of the leading causes of mortality and
morbidity worldwide. A chronic and debilitating condition by nature, TBI is reportedly …
morbidity worldwide. A chronic and debilitating condition by nature, TBI is reportedly …
Glipizide ameliorates human poly (Q) mediated neurotoxicity by upregulating insulin signalling in Drosophila disease models
S Tandon, S Sarkar - Biochemical and Biophysical Research …, 2023 - Elsevier
Increasing reports suggest insulin signalling pathway as a putative drug target against
polyglutamine [poly (Q)] disorders, such as Huntington's disease (HD), Spinocerebellar …
polyglutamine [poly (Q)] disorders, such as Huntington's disease (HD), Spinocerebellar …
Glutamine stimulates the S6K/4E-BP branch of insulin signalling pathway to mitigate human poly(Q) disorders in Drosophila disease models
S Tandon, S Sarkar - Nutritional Neuroscience, 2024 - Taylor & Francis
ABSTRACT Human polyglutamine [poly (Q)] disorders such as Huntington's disease,
different types of ataxias, etc. are devastating brain illnesses which are characterised by the …
different types of ataxias, etc. are devastating brain illnesses which are characterised by the …
Myc functions downstream of InR and their concurrent upregulation additively restricts pathogenesis of human poly (Q) disorders in Drosophila disease models
S Tandon, S Sarkar - The International Journal of Biochemistry & Cell …, 2024 - Elsevier
Abstract Human polyglutamine [poly (Q)] disorders are caused by abnormal expansion of
CAG repeats in one gene (disease specific), yet a plethora of cellular pathways are found to …
CAG repeats in one gene (disease specific), yet a plethora of cellular pathways are found to …
Generation of Functioning Platelets from Mature Megakaryocytes Derived from CD34+ Umbilical Cord Blood Cells
Z Zhong, C Chen, N Wang, Y Qiu, X Li… - Stem Cells and …, 2024 - liebertpub.com
Clinically patients with thrombocytopenia are in urgent need of platelet transfusion, thus it is
necessary to produce the platelets in large scale in vitro to meet the clinical needs. In this …
necessary to produce the platelets in large scale in vitro to meet the clinical needs. In this …
Reinstated Activity of Human Tau-induced Enhanced Insulin Signaling Restricts Disease Pathogenesis by Regulating the Functioning of Kinases/Phosphatases and …
Pragati, S Sarkar - Molecular Neurobiology, 2024 - Springer
Tauopathies such as Alzheimer's disease (AD), Frontotemporal dementia, and parkinsonism
linked to chromosome 17 (FTDP-17), etc. are characterized by tau hyperphosphorylation …
linked to chromosome 17 (FTDP-17), etc. are characterized by tau hyperphosphorylation …
Drosophila as a model to study autophagy in neurodegenerative diseases and digestive tract
Autophagy regulates cellular homeostasis by degrading and recycling cytosolic components
and damaged organelles. Disruption of autophagic flux has been shown to induce or …
and damaged organelles. Disruption of autophagic flux has been shown to induce or …