Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …

Despite substantial investments by government, philanthropic, and commercial sources over
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …

Traumatic brain injury (TBI) is one of the world's leading causes of morbidity and mortality
among young individuals. TBI applies powerful rotational and translational forces to the …

The possibility that hypothermia during or after resuscitation from asphyxia at birth, or
cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …

Traumatic brain injury (TBI) from penetrating or closed forces to the cranium can result in a
range of forms of neural damage, which culminate in mortality or impart mild to significant …

This article reviews published experimental and clinical evidence for the benefits of modest
hypothermia in the treatment of traumatic brain injury (TBI). Therapeutic hypothermia has …

Amyloid precursor protein (APP) has previously been shown to increase following traumatic
brain injury (TBI). Whereas a number of investigators assume that increased APP may lead …

Hyperthermia, frequently seen in patients following traumatic brain injury (TBI), may be due
to posttraumatic cerebral inflammation, direct hypothalamic damage, or secondary infection …

Mild or moderate hypothermia is generally thought to block all changes in signaling events
that are detrimental to ischemic brain, including ATP depletion, glutamate release, Ca2+ …

Introduction: Both for hemicraniectomy and for hypothermia, several reports describe a
beneficial effect in patients with malignant supratentorial cerebral ischemia. We compared …