Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

The central nervous system (CNS) has, among all organ systems in the human body, the
highest failure rate of traditional small-molecule drug development, ranging from 80–100 …

De novo heterozygous mutations in activity-dependent neuroprotective protein (ADNP)
cause autistic ADNP syndrome. ADNP mutations impair microtubule (MT) function, essential …

Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological
disorders that share common clinical features, such as language impairment, executive …

Post-traumatic stress disorder (PTSD) represents a global public health concern, affecting
about 1 in 20 individuals. The symptoms of PTSD include intrusiveness (involuntary …

Background ADNP is essential for embryonic development. As such, de novo ADNP
mutations lead to an intractable autism/intellectual disability syndrome requiring …

(1) Background: Activity-dependent neuroprotective protein (ADNP) is essential for neuronal
structure and function. Multiple de novo pathological mutations in ADNP cause the autistic …

Abstract Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …

Background Although many studies reported a close relationship between depression and
Alzheimer's disease (AD), the underlying pathophysiological mechanism remains unclear …

Looking at the puzzle that depicts the molecular determinants in neurodegeneration, many
pieces are lacking and multiple interconnections among key proteins and intracellular …