Cellular cooperation: insights from microbes
H Celiker, J Gore - Trends in cell biology, 2013 - cell.com
Cooperation between cells is a widespread phenomenon in nature, found across diverse
systems ranging from microbial populations to multicellular organisms. For cooperation to …
systems ranging from microbial populations to multicellular organisms. For cooperation to …
Resurrecting complexity: the interplay of plasticity and rapid evolution in the multiple trait response to strong changes in predation pressure in the water flea Daphnia …
A resurrection ecology reconstruction of 14 morphological, life history and behavioural traits
revealed that a natural Daphnia magna population rapidly tracked changes in fish predation …
revealed that a natural Daphnia magna population rapidly tracked changes in fish predation …
Drug dependence in cancer is exploitable by optimally constructed treatment holidays
J Maltas, ST Killarney, KR Singleton… - Nature ecology & …, 2024 - nature.com
Cancers with acquired resistance to targeted therapy can become simultaneously
dependent on the presence of the targeted therapy drug for survival, suggesting that …
dependent on the presence of the targeted therapy drug for survival, suggesting that …
Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance
Antimicrobial resistance was estimated to be associated with 4.95 million deaths worldwide
in 2019. It is possible to frame the antimicrobial resistance problem as a feedback-control …
in 2019. It is possible to frame the antimicrobial resistance problem as a feedback-control …
Evolving generalists in switching rugged landscapes
Evolving systems, be it an antibody repertoire in the face of mutating pathogens or a
microbial population exposed to varied antibiotics, constantly search for adaptive solutions …
microbial population exposed to varied antibiotics, constantly search for adaptive solutions …
Environmental dependence of genetic constraint
The epistatic interactions that underlie evolutionary constraint have mainly been studied for
constant external conditions. However, environmental changes may modulate epistasis and …
constant external conditions. However, environmental changes may modulate epistasis and …
Optimality in evolution: new insights from synthetic biology
Highlights•Synthetic biology provides new tools for studying optimality in evolution.•
Optimization studies reveal evolutionary constraints.•Tradeoffs are central to understanding …
Optimization studies reveal evolutionary constraints.•Tradeoffs are central to understanding …
Evolution in alternating environments with tunable interlandscape correlations
Natural populations are often exposed to temporally varying environments. Evolutionary
dynamics in varying environments have been extensively studied, although understanding …
dynamics in varying environments have been extensively studied, although understanding …
[HTML][HTML] Comprehensive analysis of mutations in the hepatitis delta virus genome based on full-length sequencing in a nationwide cohort study and evolutionary …
E Shirvani-Dastgerdi, S Amini-Bavil-Olyaee… - Clinical Microbiology …, 2015 - Elsevier
Delta hepatitis, caused by co-infection or super-infection of hepatitis D virus (HDV) in
hepatitis B virus (HBV)-infected patients, is the most severe form of chronic hepatitis, often …
hepatitis B virus (HBV)-infected patients, is the most severe form of chronic hepatitis, often …
The strength of genetic interactions scales weakly with mutational effects
A Velenich, J Gore - Genome biology, 2013 - Springer
Background Genetic interactions pervade every aspect of biology, from evolutionary theory,
where they determine the accessibility of evolutionary paths, to medicine, where they can …
where they determine the accessibility of evolutionary paths, to medicine, where they can …