Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …

Nanotechnology in medical applications, especially in oncology as drug delivery systems,
has recently shown promising results. However, although these advances have been …

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with
high mortality. We used a systematic drug repositioning bioinformatics approach querying a …

G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules
involved in signal transmission. These receptors play key physiological roles and their …

G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …

In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory
autocrine and paracrine signals, involving overexpression of secreted peptide growth …

G protein‐coupled receptor (GPCR) agonists, including neurotransmitters, hormones,
chemokines, and bioactive lipids, act as potent cellular growth factors and have been …