Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary
kidney disease and one of the most common causes of end-stage kidney disease. Multiple …

Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD)
progression in mouse models, but whether the effect was due to solely reduced calories or …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common,
potentially lethal, monogenic diseases and is caused predominantly by mutations in …

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the
polycystin 1 (PKD1) or polycystin 2 genes, presents with progressive development of kidney …

Ketogenic dietary interventions (KDIs) are beneficial in animal models of autosomal-
dominant polycystic kidney disease (ADPKD). KETO-ADPKD, an exploratory, randomized …

The association of overweight/obesity with disease progression in patients with autosomal
dominant polycystic kidney disease (ADPKD) remains untested. We hypothesized that …

Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder
marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that …

Background The major gene mutated in autosomal dominant polycystic kidney disease was
first identified over 20years ago, yet its function remains poorly understood. We have used a …

Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic
cause of ESKD, is characterized by relentless development of kidney cysts, hypertension …