The impact of ACE and ACE2 gene polymorphisms in pulmonary diseases including COVID-19

I Gintoni, M Adamopoulou, C Yapijakis - in vivo, 2022 - iv.iiarjournals.org
Chronic and acute respiratory diseases pose a major problem for public health worldwide
due to the high morbidity and mortality rates, while treatment options remain mostly …

[HTML][HTML] Angiotensin–Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms

N Yamamoto, N Nishida, R Yamamoto, T Gojobori… - Genes, 2021 - mdpi.com
The renin–angiotensin–aldosterone system (RAAS) appears to play an important role in
SARS-CoV-2 infection. Polymorphisms within the genes that control this enzymatic system …

[HTML][HTML] ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

LE Martinez-Gomez, B Herrera-Lopez… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
current coronavirus disease 2019 (COVID-19) pandemic, affecting more than 219 countries …

Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study

O Gunal, O Sezer, GU Ustun, CE Ozturk… - Annals of Saudi …, 2021 - annsaudimed.net
BACKGROUND: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D)
polymorphism may play a role in the pathogenesis of coronavirus-19 disease (COVID-19) …

[HTML][HTML] Angiotensin-Converting Enzyme (ACE) level, but not ACE gene polymorphism, is associated with prognosis of COVID-19 infection: Implications for diabetes …

O Elbasan, F Bayram, CD Yazan, T Apaydın… - PloS one, 2023 - journals.plos.org
Background The renin-angiotensin-aldosterone system was shown to be activated in severe
COVID-19 infection. We aimed to investigate the relationship between angiotensin …

[HTML][HTML] Ace2 and innate immunity in the regulation of SARS-CoV-2-induced acute lung injury: A review

L Qu, C Chen, T Yin, Q Fang, Z Hong, R Zhou… - International journal of …, 2021 - mdpi.com
Despite the protracted battle against coronavirus acute respiratory infection (COVID-19) and
the rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] The renin-angiotensin system as a component of biotrauma in acute respiratory distress syndrome

K Krenn, V Tretter, F Kraft, R Ullrich - Frontiers in Physiology, 2022 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a major concern in critical care medicine with
a high mortality of over 30%. Injury to the lungs is caused not only by underlying …

ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a meta-analysis

TJ Oscanoa, X Vidal, E Coto… - Arterial …, 2021 - journals.viamedica.pl
Background: Hypertension and type 2 diabetes increase the risk of severe SARS-CoV-2
infection. On the other hand, homozygous ACE deletion polymorphism (DD) has been …

[HTML][HTML] Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases

AD Kunvariya, SA Dave, ZJ Modi, PK Patel, SR Sagar - Heliyon, 2023 - cell.com
Abstract Angiotensin converting enzyme 2 (ACE2) is a homolog of ACE (a transmembrane
bound dipeptidyl peptidase enzyme). ACE2 converts angiotensinogen to the heptapeptide …

Association of ACE ID, MTHFR C677T, and MIF-173GC variants with the clinical course of COVID-19 patients

A Tekcan, M Cihangiroglu, M Capraz… - … Nucleotides & Nucleic …, 2023 - Taylor & Francis
The course of coronavirus disease-2019 (COVID-19) differs from person to person. The
relationship between the genetic variations of the host and the course of COVID-19 has …