Receiving a neurodegenerative disease (NDD) diagnosis, such as Alzheimer's disease,
Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis, is devastating …

G-protein-coupled receptors (GPCRs) contribute to numerous physiological processes via
complex network mechanisms. While indirect signaling assays (Ca2+ mobilization, cAMP …

Inflammatory and neuropathic-like components underlie rheumatoid arthritis (RA)-
associated pain, and lysophosphatidic acid (LPA) is linked to both joint inflammation in RA …

Ponesimod is a sphingosine 1‐phosphate (S1P) receptor (S1PR) modulator that was
recently approved for treating relapsing forms of multiple sclerosis (MS). Three other FDA …

Spinal cord injuries (SCIs) irreversibly disrupt spinal connectivity, leading to permanent
neurological disabilities. Current medical treatments for reducing the secondary damage …

G protein-coupled receptors (GPCRs) have seven transmembrane spanning domains and
comprise the largest superfamily with~ 800 receptors in humans. GPCRs are attractive …

Metabolomics has been applied to diagnose diseases, predict disease progression, and
design therapeutic strategies in various areas of medicine. However, it remains to be …

One class of molecules that are now coming to be recognized as essential for our
understanding of the nervous system are the lysophospholipids. One of the major signaling …

Neuropathic pain (NP) is a complex chronic pain state with a prevalence of almost 10% in
the general population. Pharmacological options for NP are limited and weakly effective, so …

Summary Vitamin B 12 (B 12) deficiency causes neurological manifestations resembling
multiple sclerosis (MS); however, a molecular explanation for the similarity is unknown …