During eukaryote cell division, molecular motors are crucial regulators of microtubule
organization, spindle assembly, chromosome segregation and intracellular transport. The …

Molecular motors are enzymes that convert chemical potential energy into controlled kinetic
energy for mechanical work inside cells. Understanding the biophysics of these motors is …

Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and
depolymerize microtubule plus-ends, but their mechanism of combining these distinct …

Motor proteins of the conserved kinesin-14 family have important roles in mitotic spindle
organization and chromosome segregation. Previous studies have indicated that kinesin-14 …

Kinesin-14 is a unique minus-end-directed microtubule-based motor. A swinging motion of a
class-specific N-terminal neck helix has been proposed to produce minus-end directionality …

Drosophila melanogaster kinesin-14 Ncd cross-links parallel microtubules at the spindle
poles and antiparallel microtubules within the spindle midzone to play roles in bipolar …

Kinesins are a family of force-generating enzymes that transport cellular cargos along
microtubule trackways and restructure the mitotic spindle to segregate chromosomes …

Candida albicans is a major fungal pathogen whose virulence is associated with its ability to
transition from a budding yeast form to invasive hyphal filaments. The kinesin-14 family …

Kar3Cik1 is a heterodimeric kinesin-14 from Saccharomyces cerevisiae involved in spindle
formation during mitosis and karyogamy in mating cells. Kar3 represents a canonical kinesin …

Force production by kinesins has been linked to structural rearrangements of the N and C
termini of their motor domain upon nucleotide binding. In recent crystal structures, the Kar3 …