Multi-omic profiling of the developing human cerebral cortex at the single-cell level
The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …
expression throughout development that is mediated, in part, by the spatiotemporal activity …
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease
To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-
ranging domains encompassing multiple transcriptional units, including heritability loci for …
ranging domains encompassing multiple transcriptional units, including heritability loci for …
Transcriptome and chromatin accessibility landscapes across 25 distinct human brain regions expand the susceptibility gene set for neuropsychiatric disorders
Brain region-and cell-specific transcriptomic and epigenomic molecular features are
associated with heritability for neuropsychiatric traits, but a systematic view, considering …
associated with heritability for neuropsychiatric traits, but a systematic view, considering …