[HTML][HTML] Physiological roles of transverse lipid asymmetry of animal membranes

RJ Clarke, KR Hossain, K Cao - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
The plasma membrane phospholipid distribution of animal cells is markedly asymmetric.
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are concentrated in the inner …

[HTML][HTML] Building asymmetric lipid bilayers for molecular dynamics simulations: What methods exist and how to choose one?

EH Chaisson, FA Heberle, M Doktorova - Membranes, 2023 - mdpi.com
The compositional asymmetry of biological membranes has attracted significant attention
over the last decade. Harboring more differences from symmetric membranes than …

Preparation of asymmetric phospholipid vesicles for use as cell membrane models

M Doktorova, FA Heberle, B Eicher, RF Standaert… - Nature protocols, 2018 - nature.com
Freely suspended liposomes are widely used as model membranes for studying lipid–lipid
and protein–lipid interactions. Liposomes prepared by conventional methods have …

[HTML][HTML] Different pathways for engulfment and endocytosis of liquid droplets by nanovesicles

R Ghosh, V Satarifard, R Lipowsky - Nature Communications, 2023 - nature.com
During endocytosis of nanoparticles by cells, the cellular membranes engulf the particles,
thereby forming a closed membrane neck that subsequently undergoes fission. For solid …

Experimentally determined leaflet–leaflet phase diagram of an asymmetric lipid bilayer

TA Enoki, FA Heberle - Proceedings of the National …, 2023 - National Acad Sciences
We have determined the partial leaflet–leaflet phase diagram of an asymmetric lipid bilayer
at ambient temperature using asymmetric giant unilamellar vesicles (aGUVs). Symmetric …

Understanding the structure and dynamics of complex biomembrane interactions by neutron scattering techniques

S Qian, VK Sharma, LA Clifton - Langmuir, 2020 - ACS Publications
The membrane is one of the key structural materials of biology at the cellular level.
Composed predominantly of a bilayer of lipids with embedded and bound proteins, it defines …

Multiscale lipid membrane dynamics as revealed by neutron spectroscopy

VK Sharma, E Mamontov - Progress in Lipid Research, 2022 - Elsevier
The plasma membrane is one of the principal structural components of the cell and,
therefore, one of the key components of the cellular life. Because the membrane's dynamics …

[HTML][HTML] Intrinsic curvature-mediated transbilayer coupling in asymmetric lipid vesicles

B Eicher, D Marquardt, FA Heberle, I Letofsky-Papst… - Biophysical journal, 2018 - cell.com
We measured the effect of intrinsic lipid curvature, J 0, on structural properties of asymmetric
vesicles made of palmitoyl-oleoyl-phosphatidylethanolamine (POPE; J 0< 0) and palmitoyl …

Seeing the membrane from both sides now: Lipid asymmetry and its strange consequences

M Doktorova, I Levental… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Almost all biomembranes are constructed as lipid bilayers and, in almost all of these, the two
opposing monolayers (leaflets) have distinct lipid compositions. This lipid asymmetry arises …

A mechanical mechanism for vitamin E acetate in e-cigarette/vaping-associated lung injury

M DiPasquale, O Gbadamosi… - Chemical research in …, 2020 - ACS Publications
The outbreak of electronic-cigarette/vaping-associated lung injury (EVALI) has made
thousands ill. This lung injury has been attributed to a physical interaction between toxicants …