Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Glutathione (GSH), often referred to as “the master antioxidant,” participates not only in
antioxidant defense systems, but many metabolic processes, and therefore its role cannot be …

Adaptive features of innate immunity, also termed 'trained immunity', have recently been
shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity …

Virus-induced cell death has long been thought of as a double-edged sword in the inhibition
or exacerbation of viral infections. The vital role of iron, an essential element for various …

Tuberculosis (TB) still poses a profound burden on global health, owing to significant
morbidity and mortality worldwide. Although a fully functional immune system is essential for …

The lungs are a major site of entry of pathogens into the body and thus require rapid and
effective innate responses to prevent pathogens establishing infection and to limit their …

Early clearance (EC) is the successful eradication of inhaled M ycobacterium tuberculosis
before an adaptive immune response develops. Evidence for EC comes from case contact …

Tuberculosis is the most important bacterial infection world wide. The causative agent,
Mycobacterium tuberculosis survives and proliferates within macrophages. Immune …

Glutathione (GSH) is the most abundant cellular tripeptide (L‐γ‐glutamate‐L‐cysteinyl‐
glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a …

Natural killer (NK) cells have a crucial role in combating infections and cancers and their
surface receptors can directly recognize and respond to damaged, transformed or non-self …