The epitranscriptome beyond m6A
D Wiener, S Schwartz - Nature Reviews Genetics, 2021 - nature.com
Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
[HTML][HTML] Epigenetic modification of m6A regulator proteins in cancer
Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
[HTML][HTML] Small RNAs are modified with N-glycans and displayed on the surface of living cells
Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …
[HTML][HTML] RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
X Lin, G Chai, Y Wu, J Li, F Chen, J Liu, G Luo… - Nature …, 2019 - nature.com
Abstract N6-Methyladenosine (m6A) modification has been implicated in the progression of
several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one …
several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one …
MODOMICS: a database of RNA modification pathways. 2017 update
P Boccaletto, MA Machnicka, E Purta… - Nucleic acids …, 2018 - academic.oup.com
MODOMICS is a database of RNA modifications that provides comprehensive information
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …
[HTML][HTML] Dynamic RNA modifications in gene expression regulation
Over 100 types of chemical modifications have been identified in cellular RNAs. While the
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …
[HTML][HTML] RNA N6-methyladenosine modification in cancers: current status and perspectives
Abstract N 6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
Genomics in the long-read sequencing era
EL van Dijk, D Naquin, K Gorrichon, Y Jaszczyszyn… - Trends in Genetics, 2023 - cell.com
Long-read sequencing (LRS) technologies have provided extremely powerful tools to
explore genomes. While in the early years these methods suffered technical limitations, they …
explore genomes. While in the early years these methods suffered technical limitations, they …
Post-transcriptional gene regulation by mRNA modifications
The recent discovery of reversible mRNA methylation has opened a new realm of post-
transcriptional gene regulation in eukaryotes. The identification and functional …
transcriptional gene regulation in eukaryotes. The identification and functional …
[HTML][HTML] m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells
RNA modifications play critical roles in important biological processes. However, the
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …