Breast cancer: a molecularly heterogenous disease needing subtype-specific treatments

U Testa, G Castelli, E Pelosi - Medical Sciences, 2020 - mdpi.com
Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

[HTML][HTML] Histological types of breast cancer: how special are they?

B Weigelt, FC Geyer, JS Reis-Filho - Molecular oncology, 2010 - Elsevier
Breast cancer is a heterogeneous disease, comprising multiple entities associated with
distinctive histological and biological features, clinical presentations and behaviours and …

Molecular analysis of TCGA breast cancer histologic types

A Thennavan, F Beca, Y Xia, S Garcia-Recio, K Allison… - Cell genomics, 2021 - cell.com
Breast cancer is classified into multiple distinct histologic types, and many of the rarer types
have limited characterization. Here, we extend The Cancer Genome Atlas Breast Cancer …

The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade

B Weigelt, FL Baehner… - The Journal of Pathology …, 2010 - Wiley Online Library
In the last decade, the development of microarrays and the ability to perform massively
parallel gene expression analysis of human tumours were received with great excitement by …

Histological and molecular types of breast cancer: is there a unifying taxonomy?

B Weigelt, JS Reis-Filho - Nature reviews Clinical oncology, 2009 - nature.com
Breast cancer is a complex and heterogeneous disease, comprising multiple tumor entities
associated with distinctive histological patterns and different biological features and clinical …

Refinement of breast cancer classification by molecular characterization of histological special types

B Weigelt, HM Horlings, B Kreike… - The Journal of …, 2008 - Wiley Online Library
Most invasive breast cancers are classified as invasive ductal carcinoma not otherwise
specified (IDC NOS), whereas about 25% are defined as histological 'special types'. These …

[HTML][HTML] β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

FC Geyer, M Lacroix-Triki, K Savage, M Arnedos… - Modern pathology, 2011 - Elsevier
Aberrant β-catenin expression as determined by assessment of its subcellular localization
constitutes a surrogate marker of Wnt signalling pathway activation and has been reported …

SF3B1 mutations constitute a novel therapeutic target in breast cancer

SL Maguire, A Leonidou, P Wai… - The Journal of …, 2015 - Wiley Online Library
Mutations in genes encoding proteins involved in RNA splicing have been found to occur at
relatively high frequencies in several tumour types including myelodysplastic syndromes …

Breast cancer—one term, many entities?

NR Bertos, M Park - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Breast cancer, rather than constituting a monolithic entity, comprises heterogeneous tumors
with different clinical characteristics, disease courses, and responses to specific treatments …

Molecular classification of breast cancer: what the pathologist needs to know

EA Rakha, AR Green - Pathology, 2017 - Elsevier
Breast cancer is a heterogeneous disease featuring distinct histological, molecular and
clinical phenotypes. Although traditional classification systems utilising clinicopathological …