Bile acid metabolism and signaling, the microbiota, and metabolic disease
The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …
gastrointestinal tract contributes to host health through its role in producing energy or …
Role of the gut–brain axis in energy and glucose metabolism
HR Wachsmuth, SN Weninger, FA Duca - Experimental & molecular …, 2022 - nature.com
The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …
diseases. During a meal, the gut provides crucial information to the brain regarding …
The incretin hormone GLP‐1 and mechanisms underlying its secretion: 肠促胰岛素激素GLP‐1 及其潜在的分泌机制
L Tian, T Jin - Journal of diabetes, 2016 - Wiley Online Library
摘要胰高血糖素样肽‐1 (Glucagon‐like peptide‐1, GLP‐1) 是一种细胞类型特异性的胰高血糖
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …
Treatment of type 2 diabetes: challenges, hopes, and anticipated successes
MA Nauck, J Wefers, JJ Meier - The lancet Diabetes & endocrinology, 2021 - thelancet.com
Despite the successful development of new therapies for the treatment of type 2 diabetes,
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol
The interplay between western diet and gut microbiota drives the development of non-
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …
GPCR-mediated signaling of metabolites
AS Husted, M Trauelsen, O Rudenko, SA Hjorth… - Cell metabolism, 2017 - cell.com
In addition to their bioenergetic intracellular function, several classical metabolites act as
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …
Commensal bacteria make GPCR ligands that mimic human signalling molecules
LJ Cohen, D Esterhazy, SH Kim, C Lemetre… - Nature, 2017 - nature.com
Commensal bacteria are believed to have important roles in human health. The
mechanisms by which they affect mammalian physiology remain poorly understood, but …
mechanisms by which they affect mammalian physiology remain poorly understood, but …
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Obesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and
gut barrier disruption. Microbial composition and the mechanisms of interaction with the host …
gut barrier disruption. Microbial composition and the mechanisms of interaction with the host …
The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis
A Hasani, S Ebrahimzadeh… - Journal of medical …, 2021 - microbiologyresearch.org
Alteration in the composition of the gut microbiota can lead to a number of chronic clinical
diseases. Akkermansia muciniphila is an anaerobic bacteria constituting 3–5% of the gut …
diseases. Akkermansia muciniphila is an anaerobic bacteria constituting 3–5% of the gut …
The gut microbiome influences host endocrine functions
M Rastelli, PD Cani, C Knauf - Endocrine reviews, 2019 - academic.oup.com
The gut microbiome is considered an organ contributing to the regulation of host
metabolism. Since the relationship between the gut microbiome and specific diseases was …
metabolism. Since the relationship between the gut microbiome and specific diseases was …