Rhodopsin is a specialized G protein–coupled receptor (GPCR) found in vertebrate rod
cells. Absorption of light by its 11-cis retinal chromophore leads to rapid photochemical …

Since the discovery of the first rhodopsin mutation that causes retinitis pigmentosa in 1990,
significant progresses have been made in elucidating the pathophysiology of diseases …

Helical membrane proteins are more tightly packed and the packing interactions are more
diverse than those found in helical soluble proteins. Based on a linear correlation between …

Rhodopsin, the G-protein coupled receptor in retinal rod photoreceptors, is a highly
conserved protein that undergoes several types of post-translational modifications. These …

Characterizing the pathogenicity of DNA sequence variants of unknown significance (VUS)
is a major bottleneck in human genetics, and is increasingly important in determining which …

The visual pigment rhodopsin (rh1) constitutes the first step in the sensory transduction
cascade in the rod photoreceptors of the vertebrate eye, forming the basis of vision at low …

The nonvisual ocular photoreceptor melanopsin, found in the neurons of vertebrate inner
retina, absorbs blue light and triggers the “biological clock” of mammals by activating the …

Mutations in rhodopsin, the visual pigment found in rod cells, account for a large fraction of
genetic changes underlying the human retinal diseases, Retinitis Pigmentosa (RP). The …

G protein-coupled receptors (GPCRs) are crucial sensors of extracellular signals in
eukaryotes, and direct measurement of GPCR-mediated signaling is useful for high …

Background Sequence homology considerations widely used to transfer functional
annotation to uncharacterized protein sequences require special precautions in the case of …