KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks
DC Di Giammartino, A Kloetgen, A Polyzos, Y Liu… - Nature cell …, 2019 - nature.com
Cell fate transitions are accompanied by global transcriptional, epigenetic and topological
changes driven by transcription factors, as is exemplified by reprogramming somatic cells to …
changes driven by transcription factors, as is exemplified by reprogramming somatic cells to …
Biological functions of HMGN chromosomal proteins
Chromatin plays a key role in regulating gene expression programs necessary for the
orderly progress of development and for preventing changes in cell identity that can lead to …
orderly progress of development and for preventing changes in cell identity that can lead to …
Roles of OCT4 in pathways of embryonic development and cancer progression
SK Patra - Mechanisms of ageing and development, 2020 - Elsevier
Somatic cells may be reprogrammed to pluripotent state by ectopic expression of certain
transcription factors; namely, OCT4, SOX2, KLF4 and c-MYC. However, the molecular and …
transcription factors; namely, OCT4, SOX2, KLF4 and c-MYC. However, the molecular and …
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
Chromatin organization is a highly orchestrated process that influences gene expression, in
part by modulating access of regulatory factors to DNA and nucleosomes. Here, we report …
part by modulating access of regulatory factors to DNA and nucleosomes. Here, we report …
Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins
White adipose tissue browning is a key metabolic process controlled by epigenetic factors
that facilitate changes in gene expression leading to altered cell identity. We find that male …
that facilitate changes in gene expression leading to altered cell identity. We find that male …
H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors
S Zhang, Y Postnikov, A Lobanov, T Furusawa… - Communications …, 2022 - nature.com
Nucleosomes containing acetylated H3K27 are a major epigenetic mark of active chromatin
and identify cell-type specific chromatin regulatory regions which serve as binding sites for …
and identify cell-type specific chromatin regulatory regions which serve as binding sites for …
AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation
Y Sekita, Y Sugiura, A Matsumoto, Y Kawasaki… - Stem cell research & …, 2021 - Springer
Abstract Background Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular
proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the …
proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the …
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin
Background Nucleosomal binding proteins, HMGN, is a family of chromatin architectural
proteins that are expressed in all vertebrate nuclei. Although previous studies have …
proteins that are expressed in all vertebrate nuclei. Although previous studies have …
Chromatin binding protein HMGN1 promotes HBV cccDNA transcription and replication by regulating the phosphorylation of histone 3
T Ming, L Yuting, D Meiling, C Shengtao, R Jihua… - Antiviral Research, 2024 - Elsevier
Background and aims Direct elimination of cccDNA remains a formidable obstacle due to
the persistent and stable presence of cccDNA in hepatocyte nuclei. The silencing of cccDNA …
the persistent and stable presence of cccDNA in hepatocyte nuclei. The silencing of cccDNA …
CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation
Y Ran, S Huang, J Shi, Q Feng, Y Deng, AP Xiang… - RNA biology, 2022 - Taylor & Francis
It has recently been shown that CFIm25, a canonical mRNA 3'processing factor, could play a
variety of physiological roles through its molecular function in the regulation of mRNA …
variety of physiological roles through its molecular function in the regulation of mRNA …